966 ADVANCED ECHOCARDIOGRAPHIC AND CMR FEATURES OF PATIENTS WITH REPAIRED TETRALOGY OF FALLOT IN THE LONG-TERM FOLLOW-UP

Abstract Advanced echocardiographic and CMR features of patients with repaired Tetralogy Fallot in the long-term follow-up. Anna Gozzi1, Jolanda Sabatino1, Elena Cuppini1, Irene Cattapan1, Alessia Basso1, Jennifer Fumanelli1, Angela Di Candia1, Martina Avesani1, Domenico Sirico1, Biagio Castaldi1, Reffo1, Cerutti1, Roberta Biffanti1, Giovanni Salvo1 1Department for Women's Children's Health, University Hospital Padova, Pediatric Congenital Cardiology Unit, Via Nicolo` Giustiniani, 2, 35128 Italy Background (ToF) is most common cyanotic congenital heart disease population ToF repair survivors growing rapidly. Children and, more frequently young adults, develop late complications. Sudden cardiac death life-threatening ventricular arrhythmia remain a concern tetralogy Fallot. The aim this study was to describe analyse advanced follow-up find non-invasive predictors adverse prognosis. Methods This retrospective cohort study. Consecutive 200 who did not undergo pulmonary valve replacement were included. Mean age all 19 ± 8. electrocardiographic (ECG), cardiopulmonary exercise testing (CPET), magnetic resonance (CMR) data reviewed retrospectively. Right myocardial work index (RWI) calculated as area right pressure strain loops. From RWI, Constructive Work (RCW), Wasted (RWW) Efficiency (RWE) estimated. Patients screened according at surgery (<12 months >12 months) time since (< 25 years ≥ years). A composite end-point major cardiovascular events (sudden death, sustained non-sustained tachycardia, resuscitated sudden or syncope) used. Results CPET values significantly different than corrective surgery. Left ejection fraction measured either by echocardiography slightly but reduced older (>12 have V02max CPET, larger RA LA areas RV basal diameter. During median 2.9 years, 1 patient died suddenly, 5 had documented other 4 syncope. On univariate analysis, left atrial area/BSA (P=0.044) longitudinal (P=0.010) related combined end point. reported VT Holter ECG presented function terms CMR-EF, FAC RWI. Finally, TOF borderline/impaired predicted VO2 max freewall index. Conclusion Long-term survival clinical condition after surgical correction infancy generally good functional status - operated could be excellent up repair. However, relative compared those undergoing early evaluation are usually worse prognosis, recurrency TOF. feasible TOF; disadvantageous may sensitive indicator impairment standard parameters, able predict capacity.